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Issue 109, 2016, Issue in Progress
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Few molecule SERS detection using nanolens based plasmonic nanostructure: application to point mutation detection

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Abstract

Advancements in nanotechnology fabrication techniques allow the possibility to design and fabricate a device with a minimum gap (<10 nm) between the composing nanostructures in order to obtain better control over the creation and spatial definition of plasmonic hot-spots. The present study is intended to show the fabrication of nanolens and their application to single/few molecules detection. Theoretical simulations were performed on different designs of real structures, including comparison of rough and smooth surfaces. Various molecules (rhodamine 6G, benzenethiol and BRCA1/BRCT peptides) were examined in this regard. Single molecule detection was possible for synthetic peptides, with a possible application in early detection of diseases.

Graphical abstract: Few molecule SERS detection using nanolens based plasmonic nanostructure: application to point mutation detection

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Article information


Submitted
19 Sep 2016
Accepted
23 Oct 2016
First published
27 Oct 2016

RSC Adv., 2016,6, 107916-107923
Article type
Paper

Few molecule SERS detection using nanolens based plasmonic nanostructure: application to point mutation detection

G. Das, S. Alrasheed, M. L. Coluccio, F. Gentile, A. Nicastri, P. Candeloro, G. Cuda, G. Perozziello and E. Di Fabrizio, RSC Adv., 2016, 6, 107916 DOI: 10.1039/C6RA23301E

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