New cadinane sesquiterpenoids from the basidiomycetous fungus Pholiota sp.

Jie Lin; Renlei Wang; Guohua Xu; Zhengfeng Ding; Xueshen Zhu; Xingzhong Liu; Jian Zou; Guodong Chen; Li Li; Ling Liu

doi:10.1039/C6RA22448B

New cadinane sesquiterpenoids from the basidiomycetous fungus Pholiota sp.†

Jie Lin,^a Renlei Wang,^a Guohua Xu,^a Zhengfeng Ding,^a Xueshen Zhu,^a Xingzhong Liu,^b Jian Zou,^c Guodong Chen,^c Li Li^d and Ling Liu*^b

Author affiliations

* Corresponding authors

^a Jiangsu Key Laboratory for Biofunctional Molecules, College of Life Science and Chemistry, Jiangsu Second Normal University, 77 West Beijing Road, Nanjing 210013, P. R. China

^b State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, P. R. China
E-mail: liul@im.ac.cn.
Tel: +86 10 64806153

^c Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China

^d Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, P. R. China

Abstract

Five new cadinane sesquiterpenoids, pholiotins A–E (1–5), and three known compounds, 11-hydroxy-1(10)-valencen-2-one (6), 8,11-dihydroxy-1(10)-eremophilen-2-one (7) and durgamone (8), were isolated from the crude extract of Pholiota sp. Their structures were established on the basis of extensive spectroscopic analysis. Their absolute configurations were determined by X-ray diffraction, the Snatzke's method and electronic circular dichroism (ECD) calculations. All isolates were tested for antifungal activity.

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New cadinane sesquiterpenoids from the basidiomycetous fungus Pholiota sp.†

Abstract

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New cadinane sesquiterpenoids from the basidiomycetous fungus Pholiota sp.

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