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Issue 104, 2016, Issue in Progress
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Anti selective glycolate aldol reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one: application towards the asymmetric synthesis of 8-4′-oxyneolignans

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Abstract

The anti selective glycolate aldol reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one auxiliary have been standardized with high yields and excellent diastereoselectivities on various substituted aryl, allyl and alkyl aldehydes. The optimized reaction conditions were employed for the stereoselective synthesis of oxyneolignans.

Graphical abstract: Anti selective glycolate aldol reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one: application towards the asymmetric synthesis of 8-4′-oxyneolignans

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Article information


Submitted
02 Sep 2016
Accepted
04 Oct 2016
First published
14 Oct 2016

RSC Adv., 2016,6, 102116-102126
Article type
Paper

Anti selective glycolate aldol reactions of (S)-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one: application towards the asymmetric synthesis of 8-4′-oxyneolignans

M. Gangar, A. Ittuveetil, S. Goyal, A. Pal, Harikrishnan M. and V. A. Nair, RSC Adv., 2016, 6, 102116
DOI: 10.1039/C6RA22026F

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