Issue 100, 2016, Issue in Progress

CuI-catalyzed amination of Tröger's base halides: a convenient method for synthesis of unsymmetrical Tröger's bases

Abstract

A convenient method for the amination of Tröger's base halides has been developed via copper catalyzed coupling reactions. This reaction proceeds in moderate to good yields. The protocol has been utilized to produce two different classes of Tröger's base derivatives, one bearing identical substituents on both the aryl rings and the other featuring two different substituents on the aryl rings.

Graphical abstract: CuI-catalyzed amination of Tröger's base halides: a convenient method for synthesis of unsymmetrical Tröger's bases

Supplementary files

Article information

Article type
Paper
Submitted
26 Aug 2016
Accepted
08 Oct 2016
First published
10 Oct 2016

RSC Adv., 2016,6, 98297-98305

CuI-catalyzed amination of Tröger's base halides: a convenient method for synthesis of unsymmetrical Tröger's bases

M. B. Reddy, P. G. Reddy, M. Shailaja, A. Manjula and T. P. Rao, RSC Adv., 2016, 6, 98297 DOI: 10.1039/C6RA21437A

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