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Issue 105, 2016, Issue in Progress
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Carbon dots-based ratiometric nanosensor for highly sensitive and selective detection of mercury(II) ions and glutathione

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Abstract

Glutathione (GSH) plays a crucial role in many cellular processes. Recently, great efforts have been made to develop efficient methods for GSH sensing in organisms. Herein, we reported the design and application of a specific ratiometric fluorescent probe, which contained carbon quantum dots (CDs) as sensing signal and Rhodamine B (RhB) as reference, for highly sensitive detection of mercury ions (Hg2+) and glutathione (GSH). The obtained nanosensor showed characteristic fluorescence emissions of CDs and RhB under a single excitation wavelength. The functional CDs were first synthesized in our laboratory according to a one-pot pyrolysis process of sodium citrate with histidine. In the presence of Hg2+, only the fluorescence of CDs was quenched due to electron transfer between Hg2+ and functional groups on the surface of CDs. Subsequently, the fluorescence of CDs–Hg2+ system was recovered gradually with the addition of GSH due to their stronger affinity with Hg2+, which could effectively exclude numerous background interferences. This method has been successfully applied to oxidative stress model investigation. The proposed ratiometric sensing strategy was proven to be facile, reliable, sensitive and selective, showing great potential for Hg2+ and GSH detection in environmental monitoring and biological detection.

Graphical abstract: Carbon dots-based ratiometric nanosensor for highly sensitive and selective detection of mercury(ii) ions and glutathione

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Publication details

The article was received on 24 Aug 2016, accepted on 14 Oct 2016 and first published on 21 Oct 2016


Article type: Paper
DOI: 10.1039/C6RA21309J
Citation: RSC Adv., 2016,6, 103169-103177
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    Carbon dots-based ratiometric nanosensor for highly sensitive and selective detection of mercury(II) ions and glutathione

    S. Lu, D. Wu, G. Li, Z. Lv, Z. Chen, L. Chen, G. Chen, L. Xia, J. You and Y. Wu, RSC Adv., 2016, 6, 103169
    DOI: 10.1039/C6RA21309J

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