Synthesis of N-aryl 2-quinolinones via intramolecular C(sp2)–H amidation of Knoevenagel products†
Abstract
A practical synthesis of N-aryl 2-quinolinones via K2S2O8-mediated intramolecular C(sp2)–H amidation of Knoevenagel products was developed. The reaction proceeded smoothly in a biphasic solvent system composed of n-butyl acetate and H2O.