Synthesis of 3-arylindole derivatives from nitroalkane precursors

Chia-Yu Huang; Chun-Wei Kuo; Ashok Konala; Tang-Hao Yang; Lyu Lin; Yu-Wen Chen; Veerababurao Kavala; Ching-Fa Yao

doi:10.1039/C6RA21144E

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Synthesis of 3-arylindole derivatives from nitroalkane precursors†

Chia-Yu Huang,‡^a Chun-Wei Kuo,‡^a Ashok Konala,^a Tang-Hao Yang,^a Lyu Lin,^a Yu-Wen Chen,^a Veerababurao Kavala^a and Ching-Fa Yao*^a

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* Corresponding authors

^a Department of Chemistry, National Taiwan Normal University, 88, section 4, Tingchow road, Taipei, Taiwan 116, Republic of China
E-mail: cheyaocf@ntnu.edu.tw

Abstract

3-Arylindole derivatives were synthesized by Cu(I) catalysed intramolecular Ullmann coupling of 2-bromoarylaminoalkanes. 2-Bromoarylaminoalkanes were synthesized from 2-bromoarylnitroalkanes, which in turn prepared through AlCl₃-mediated Friedel–Crafts alkylation of bromo-substituted β-nitrostyrenes and arenes.

This article is part of the themed collection: Elegant Synthetic Routes to Indole Derivatives

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Article information

DOI: https://doi.org/10.1039/C6RA21144E
Article type: Paper
Submitted: 23 Aug 2016
Accepted: 02 Oct 2016
First published: 03 Oct 2016

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RSC Adv., 2016,6, 96049-96056

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Synthesis of 3-arylindole derivatives from nitroalkane precursors

C. Huang, C. Kuo, A. Konala, T. Yang, L. Lin, Y. Chen, V. Kavala and C. Yao, RSC Adv., 2016, 6, 96049 DOI: 10.1039/C6RA21144E

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Synthesis of 3-arylindole derivatives from nitroalkane precursors†

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Synthesis of 3-arylindole derivatives from nitroalkane precursors

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