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Issue 101, 2016, Issue in Progress
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Recent developments in the synthesis of condensed β-lactams

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Abstract

β-Lactams are important heterocycles with diverse pharmacological profiles and have emerged as useful organic synthons. Different variants of β-lactams condensed with carbo-/heterocycles, which have a broad range of antimicrobial activities and other useful pharmacological activities, justify a renewed interest in their synthetic developments. This review embraces an array of different reports on condensed β-lactams dating back to 2000. The aim of this review is to provide practicing and aspiring β-lactam chemists with a survey and flavor of the types of reactions used to prepare nonconventional condensed-β-lactams, and an insight into why certain methodologies are advantageous under particular circumstances.

Graphical abstract: Recent developments in the synthesis of condensed β-lactams

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Article information


Submitted
20 Aug 2016
Accepted
28 Sep 2016
First published
05 Oct 2016

RSC Adv., 2016,6, 99220-99250
Article type
Review Article

Recent developments in the synthesis of condensed β-lactams

Y. Kumar, P. Singh and G. Bhargava, RSC Adv., 2016, 6, 99220
DOI: 10.1039/C6RA20973D

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