n-Bu4NI/TBHP-catalyzed C–N bond formation via cross-dehydrogenative coupling of 1H-1,2,4-triazoles (N–H) and methylarenes (Csp3–H)

Abstract

An efficient n-Bu₄NI/TBHP-catalyzed protocol for C–N bond formation via cross-dehydrogenative coupling of 1H-1,2,4-triazoles (N–H) and methylarenes (C_sp³–H) has been developed under metal free conditions. A series of methylarenes and 1H-1,2,4-triazoles are tolerated in this method and gave the corresponding 1-benzyl-1,2,4-triazoles in moderate to good yields.