Issue 85, 2016
From the journal:

RSC Advances

N-Heterocyclic carbene copper(i) complex-catalyzed synthesis of 2-aryl benzoxazoles and benzothiazoles†

Julio I. Urzúa,a   Renato Contreras,b   Cristian O. Salasa  and  Ricardo A. Tapia*a  

* Corresponding authors

a Facultad de Química, Pontificia Universidad Católica de Chile, Código Postal 6094411, Santiago, Chile
E-mail: rtapia@uc.cl

b Departamento de Química, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile

Abstract

A new and efficient synthesis of 2-arylbenzoxazoles and benzothiazoles using a copper N-heterocyclic carbene complex is described. In a simple protocol a variety of 2-substituted benzoxazoles and benzothiazoles were obtained via intramolecular coupling cyclization of 2-haloanilides/2-halothioanilides in good to excellent yields.

Graphical abstract: N-Heterocyclic carbene copper(i) complex-catalyzed synthesis of 2-aryl benzoxazoles and benzothiazoles

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Article information

DOI
https://doi.org/10.1039/C6RA18510J
Article type
Paper
Submitted
20 Jul 2016
Accepted
24 Aug 2016
First published
25 Aug 2016

RSC Adv., 2016,6, 82401-82408

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N-Heterocyclic carbene copper(I) complex-catalyzed synthesis of 2-aryl benzoxazoles and benzothiazoles

J. I. Urzúa, R. Contreras, C. O. Salas and R. A. Tapia, RSC Adv., 2016, 6, 82401 DOI: 10.1039/C6RA18510J

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