Isolation of multiantennary N-glycans from glycoproteins for hepatocyte specific targeting via the asialoglycoprotein receptor

Abstract

The asialoglycoprotein receptor (ASGPR) expressed on parenchymal liver cells specifically binds multivalent carbohydrates from desialylated glycoproteins. This feature offers a huge potential for hepatocyte specific drug targeting. In this study, multiantennary N-glycans from asialofetuin have been isolated to actively target the asialoglycoprotein receptor on human hepatocellular carcinoma cells in vitro.