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Issue 95, 2016
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The role of fluids in high-pressure polymorphism of drugs: different behaviour of β-chlorpropamide in different inert gas and liquid media

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Abstract

The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1 : 1 pentane–isopentane mixture.

Graphical abstract: The role of fluids in high-pressure polymorphism of drugs: different behaviour of β-chlorpropamide in different inert gas and liquid media

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Article information


Submitted
12 Jul 2016
Accepted
21 Sep 2016
First published
21 Sep 2016

This article is Open Access

RSC Adv., 2016,6, 92629-92637
Article type
Paper

The role of fluids in high-pressure polymorphism of drugs: different behaviour of β-chlorpropamide in different inert gas and liquid media

B. A. Zakharov, Y. V. Seryotkin, N. A. Tumanov, D. Paliwoda, M. Hanfland, A. V. Kurnosov and E. V. Boldyreva, RSC Adv., 2016, 6, 92629
DOI: 10.1039/C6RA17750F

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