Installing tungsten Fischer carbene complexes into a calixarene framework

M. D'Acunto; S. Tommasone; C. Talotta; G. Brancatelli; S. Geremia; E. Valletta; F. Marino Merlo; B. Macchi; C. Gaeta; P. Neri; A. Spinella

doi:10.1039/C6RA17326H

Installing tungsten Fischer carbene complexes into a calixarene framework†

M. D'Acunto,*^a S. Tommasone,^a C. Talotta,^a G. Brancatelli,^b S. Geremia,^b E. Valletta,^c F. Marino Merlo,^d B. Macchi,^c C. Gaeta,^a P. Neri*^a and A. Spinella*^a

Author affiliations

* Corresponding authors

^a Dipartimento di Chimica e Biologia “A. Zambelli”, Università di Salerno, Via Giovanni Paolo II 132, I-84084 Fisciano, Salerno, Italy
E-mail: mdacunto@unisa.it, neri@unisa.it, spinella@unisa.it

^b Centro di Eccellenza in Biocristallografia, Dipartimento di Scienze Chimiche e Farmaceutiche, Università, di Trieste, via L. Giorgieri 1, I-34127 Trieste, Italy

^c Dipartimento di Medicina dei Sistemi, Università di Roma Tor Vergata, Via Montpellier 1, I-00133 Roma, Italy

^d Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche e Ambientali, Università di Messina, Viale F. Stagno d'Al-contres 31, I-98166 Messina, Italy

Abstract

The synthesis of the first examples of calix[4]arene-based Fischer carbene complexes is reported here. Fischer carbene complex 2 is the key intermediate to reach uracil-like derivatives 3 and 4. X-ray and NMR studies revealed that the uracyl-like synthon gives rise to a supramolecular dimer. The organometallic calixarene complexes showed a promising cytotoxicity towards human tumor cell lines.

RSC Advances

Installing tungsten Fischer carbene complexes into a calixarene framework†

Abstract

Supplementary files

Article information

Download Citation

Permissions

Installing tungsten Fischer carbene complexes into a calixarene framework

Social activity

Search articles by author

Spotlight

Advertisements