Issue 90, 2016, Issue in Progress

Monitoring quality consistency of Ixeris sonchifolia (Bunge) Hance injection by integrating UV spectroscopic fingerprints, a multi-wavelength fusion fingerprint method, antioxidant activities and UHPLC/Q-TOF-MS

Abstract

Traditional Chinese medicines/herbal medicines (TCM/HM) are too complicated mixture systems to investigate their quality consistency effectively using a single detection technique. Hence, finding an integrated, rapid and effective quality control method is of great importance. In the present study, a novel strategy integrating ultra violet (UV) spectroscopic fingerprints and multi-wavelength fusion fingerprints has been proposed for quality consistency of the popular patent medicine Ixeris sonchifolia (Bge.) Hance Injection (ISHI). The quality grades of 28 batches of the ISHI samples were evaluated by the systematic quantitative fingerprint method (SQFM) from qualitative and quantitative perspectives. As a result, UV spectroscopic fingerprints agree well with multi-wavelength fusion fingerprints. In order to investigate the chemical components of the ISHI sample, ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC/Q-TOF-MS) has been exploited in the negative ion mode, providing an important chemical structure foundation for further bioactivity and quality control studies. In addition, the orthogonal projection to latent structures (OPLS) was established to investigate the fingerprint-efficacy relationship between high performance liquid chromatography (HPLC) fingerprints and antioxidant activities. These results indicate that integrating UV spectroscopic fingerprints and multi-wavelength fusion fingerprints coupled with antioxidant activities and UHPLC/Q-TOF-MS provide a rapid and effective approach to monitor the quality consistency of TCM/HM.

Graphical abstract: Monitoring quality consistency of Ixeris sonchifolia (Bunge) Hance injection by integrating UV spectroscopic fingerprints, a multi-wavelength fusion fingerprint method, antioxidant activities and UHPLC/Q-TOF-MS

Article information

Article type
Paper
Submitted
25 Jun 2016
Accepted
07 Sep 2016
First published
08 Sep 2016

RSC Adv., 2016,6, 87616-87627

Monitoring quality consistency of Ixeris sonchifolia (Bunge) Hance injection by integrating UV spectroscopic fingerprints, a multi-wavelength fusion fingerprint method, antioxidant activities and UHPLC/Q-TOF-MS

L. Yang, X. Xie, L. Yang, J. Zhang and G. Sun, RSC Adv., 2016, 6, 87616 DOI: 10.1039/C6RA16436F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements