Issue 72, 2016, Issue in Progress

A practical and efficient route to heteraphanes: synthesis of structurally simplified analogues of ansamycins

Abstract

A highly efficient and versatile synthetic strategy has been developed for the synthesis of meta-, para-azabenzeno or azanaphthaleno phanes (II–IV) with varying ring sizes (12–25) through intramolecular Mitsunobu reaction from the corresponding Ns-arylamino alcohols. The reaction is compatible with olefin and ketone moieties in the backbone tether and has been applied in the synthesis of various simplified structural motifs of ansamycins.

Graphical abstract: A practical and efficient route to heteraphanes: synthesis of structurally simplified analogues of ansamycins

Supplementary files

Article information

Article type
Communication
Submitted
23 Jun 2016
Accepted
01 Jul 2016
First published
06 Jul 2016

RSC Adv., 2016,6, 68199-68203

A practical and efficient route to heteraphanes: synthesis of structurally simplified analogues of ansamycins

R. S. Reddy, S. Zheng, C. Lagishetti, H. You and Y. He, RSC Adv., 2016, 6, 68199 DOI: 10.1039/C6RA16247A

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