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Issue 72, 2016, Issue in Progress
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A practical and efficient route to heteraphanes: synthesis of structurally simplified analogues of ansamycins

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Abstract

A highly efficient and versatile synthetic strategy has been developed for the synthesis of meta-, para-azabenzeno or azanaphthaleno phanes (II–IV) with varying ring sizes (12–25) through intramolecular Mitsunobu reaction from the corresponding Ns-arylamino alcohols. The reaction is compatible with olefin and ketone moieties in the backbone tether and has been applied in the synthesis of various simplified structural motifs of ansamycins.

Graphical abstract: A practical and efficient route to heteraphanes: synthesis of structurally simplified analogues of ansamycins

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Publication details

The article was received on 23 Jun 2016, accepted on 01 Jul 2016 and first published on 06 Jul 2016


Article type: Communication
DOI: 10.1039/C6RA16247A
Citation: RSC Adv., 2016,6, 68199-68203
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    A practical and efficient route to heteraphanes: synthesis of structurally simplified analogues of ansamycins

    R. S. Reddy, S. Zheng, C. Lagishetti, H. You and Y. He, RSC Adv., 2016, 6, 68199
    DOI: 10.1039/C6RA16247A

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