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Issue 84, 2016, Issue in Progress
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GSH-responsive polymeric micelles based on the thio–ene reaction for controlled drug release

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Abstract

We report a glutathione (GSH) responsive drug carrier that is based on the Michael addition reaction between an olefinic bond and GSH. Amphiphilic copolymers with multi-linear-cyclized and branched structures that contain vinyl groups were successfully synthesized by deactivation enhanced atom transfer radical polymerization (DE-ATRP). The polymers self-assembled into GSH responsive micelles with sizes of 68 to 97 nm and spherical morphology. The core cross-linked micelles were confirmed to greatly decrease doxorubicin (DOX) leakage due to the concentration gradient. Drug release experiments indicated that the drug carrier containing no disulfide has the same responsive ability as a conventional GSH reduction responsive carrier with a similar polymer structure. MTT assays showed that the blank micelles are totally non-cytotoxic, while the DOX-loaded micelles exhibit GSH-dependent behaviour.

Graphical abstract: GSH-responsive polymeric micelles based on the thio–ene reaction for controlled drug release

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Supplementary files

Article information


Submitted
13 Jun 2016
Accepted
07 Aug 2016
First published
10 Aug 2016

RSC Adv., 2016,6, 80896-80904
Article type
Paper

GSH-responsive polymeric micelles based on the thio–ene reaction for controlled drug release

H. Cao, H. Song, D. Xie, C. Chen, X. Chen, P. Wang and W. Wang, RSC Adv., 2016, 6, 80896
DOI: 10.1039/C6RA15302J

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