Regioselective copper-diamine-catalyzed C–H arylation of 1,2,4-triazole ring with aryl bromides

Abstract

A convenient methodology for the regioselective C–H arylation of 1,2,4-triazole ring was developed. Using a benchtop stable Cu-diamine catalyst system, C–H functionalization of a simple 1,2,4-triazole substrate with various aryl bromides was regioselectively accomplished at the C5 position of the triazole ring.