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Issue 82, 2016
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Exploring the anti-breast cancer potential of flavonoid analogs

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Abstract

In the course of our search for new antitumor agents for breast cancer, novel flavone derivatives were synthesized, characterized and examined for their antitumor activities against breast cancer cell lines. In initial screening, analogs 7a [3-(5-amino-1,3,4-thiadiazol-2-yl)methoxy-2-phenyl-4H-chromen-4-one] and 7b [3-(5-amino-1,3,4-thiadiazol-2-yl)methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one] were found to be effective against the estrogen receptor negative cell line (MDA-MB 453), which was followed by their evaluation in five dose assays. In addition, mechanistic studies of 7a and 7b were performed by cytometric analysis and electrophoretic studies and it was observed that apoptosis is a mechanism of cell death, confirmed morphologically by acridine orange/ethidium bromide double staining and TUNEL analysis. Further in vivo evaluation of the anti-tumor activity of compound 7a and 7b by Ehrlich Ascites Carcinoma (EAC) model and related studies confirms the anti-breast cancer potential of flavonoid analogs.

Graphical abstract: Exploring the anti-breast cancer potential of flavonoid analogs

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Publication details

The article was received on 03 Jun 2016, accepted on 03 Aug 2016 and first published on 09 Aug 2016


Article type: Paper
DOI: 10.1039/C6RA14428D
RSC Adv., 2016,6, 79166-79179

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    Exploring the anti-breast cancer potential of flavonoid analogs

    V. Thakor, M. Poddar, S. Dey, S. N. Manjula, S. V. Madhunapantula, R. Pawara, H. M. Patel and M. N. Noolvi, RSC Adv., 2016, 6, 79166
    DOI: 10.1039/C6RA14428D

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