Issue 66, 2016, Issue in Progress

Diastereoselective synthesis of highly functionalized polycyclic benzosultams via tandem cyclisations of cyclic N-sulfonylimines with in situ generated Huisgen 1,4-dipoles

Abstract

Under mild reaction conditions, the tandem cycloadditions of cyclic N-sulfonylimines with in situ generated Huisgen 1,4-dipoles from dialkyl acetylenedicarboxylates and pyridines underwent readily, and delivered highly functionalized polycyclic 1,2,3,4-tetrahydropyrimidine-fused benzosultams in low to excellent chemical yields with excellent diastereoselectivities.

Graphical abstract: Diastereoselective synthesis of highly functionalized polycyclic benzosultams via tandem cyclisations of cyclic N-sulfonylimines with in situ generated Huisgen 1,4-dipoles

Supplementary files

Article information

Article type
Paper
Submitted
17 May 2016
Accepted
21 Jun 2016
First published
23 Jun 2016

RSC Adv., 2016,6, 61732-61739

Diastereoselective synthesis of highly functionalized polycyclic benzosultams via tandem cyclisations of cyclic N-sulfonylimines with in situ generated Huisgen 1,4-dipoles

H. Zhao, X. Chen, H. Pang, T. Tian, B. Li, X. Song, W. Meng, Z. Yang, Y. Zhao and Y. Liu, RSC Adv., 2016, 6, 61732 DOI: 10.1039/C6RA12771A

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