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Issue 69, 2016, Issue in Progress
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Ligand-free Pd-catalysed decarboxylative arylation of imidazo[1,2-a]pyridine-3-carboxylic acids with aryl bromides

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Abstract

A facile ligand-free method for Pd(OAc)2 catalysed decarboxylative arylation of imidazo[1,2-a]pyridine-3-carboxylic acids with hetero(aryl) bromides has been developed. This method is applicable to a variety of (hetero)aryl bromides as coupling partners. Electron withdrawing and donating groups on imidazo[1,2-a]pyridine-3-carboxylic acids are well tolerated. It represents the first general protocol for ligand-free Pd(OAc)2 catalysed decarboxylative arylation of imidazo[1,2-a]pyridine-3-carboxylic acids with (hetero)aryl halides. A few of the compounds synthesized using this protocol showed antibacterial activity against Staphylococcus aureus.

Graphical abstract: Ligand-free Pd-catalysed decarboxylative arylation of imidazo[1,2-a]pyridine-3-carboxylic acids with aryl bromides

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Supplementary files

Article information


Submitted
10 May 2016
Accepted
04 Jul 2016
First published
04 Jul 2016

RSC Adv., 2016,6, 65095-65104
Article type
Paper

Ligand-free Pd-catalysed decarboxylative arylation of imidazo[1,2-a]pyridine-3-carboxylic acids with aryl bromides

U. B. Karale, S. Kalari, J. Shivakumar, V. B. Makane, D. A. Babar, R. P. Thakare, B. N. Babu, S. Chopra and H. B. Rode, RSC Adv., 2016, 6, 65095
DOI: 10.1039/C6RA12166G

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