Issue 70, 2016, Issue in Progress

Delavatine A, a structurally unusual cyclopenta[de]isoquinoline alkaloid from Incarvillea delavayi

Abstract

Natural products have long been an important source for the discovery of biologically active compounds, in particular, drug leads. Delavatine A (1), a structurally unusual cyclopenta[de]isoquinoline alkaloid, was isolated from Incarvillea delavayi. Extensive spectroscopic analysis, in combination with biogenetic speculation, established the structure of 1. Delavatine A (1) exhibited considerable cytotoxicity against a number of cancer cell lines with IC50 values in the range of 4.28 to 6.61 μg mL−1.

Graphical abstract: Delavatine A, a structurally unusual cyclopenta[de]isoquinoline alkaloid from Incarvillea delavayi

Supplementary files

Article information

Article type
Paper
Submitted
08 May 2016
Accepted
01 Jul 2016
First published
06 Jul 2016

RSC Adv., 2016,6, 65885-65888

Delavatine A, a structurally unusual cyclopenta[de]isoquinoline alkaloid from Incarvillea delavayi

Z. Zhang, F. Yang, J. Fu, Y. Shen, W. He and W. Zhang, RSC Adv., 2016, 6, 65885 DOI: 10.1039/C6RA11915H

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