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Issue 63, 2016
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A novel process concept for the three step Boscalid® synthesis

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Abstract

Nowadays, the development of chemical processes using environmentally friendly solvents is of high importance. As an alternative to conventional reaction media based on organic solvents, we show a novel aqueous surfactant-based process concept which is used for the three step synthesis of the fungicide Boscalid®. By applying three phase microemulsion systems for the Suzuki coupling reaction, the first step within the Boscalid® synthesis, a simple product and catalyst separation can be achieved, whereby the water-soluble homogeneous Pd/SPhos catalyst complex can be reused several times. Together with an easily recyclable heterogeneous PtIr@TiO2 catalyst, which is applied for the hydrogenation reaction in the second step, followed by base-assisted condensation to the final product Boscalid® in the third step, overall yields up to 90% are achievable for the whole reaction sequence. This result was obtained without any purification step in between that requires the use of further solvents. In this way the total synthesis costs can be reduced and solvent wastage can be avoided.

Graphical abstract: A novel process concept for the three step Boscalid® synthesis

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Article information


Submitted
22 Apr 2016
Accepted
06 Jun 2016
First published
16 Jun 2016

RSC Adv., 2016,6, 58279-58287
Article type
Paper

A novel process concept for the three step Boscalid® synthesis

I. Volovych, M. Neumann, M. Schmidt, G. Buchner, J. Yang, J. Wölk, T. Sottmann, R. Strey, R. Schomäcker and M. Schwarze, RSC Adv., 2016, 6, 58279
DOI: 10.1039/C6RA10484C

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