Jump to main content
Jump to site search

Issue 63, 2016
Previous Article Next Article

Selective delivery of photothermal nanoparticles to tumors using mesenchymal stem cells as Trojan horses

Author affiliations

Abstract

The main challenge of cancer treatment is to avoid or minimize systemic side effects in off-target tissues. Mesenchymal stem cells (MSCs) can be used as therapeutical carriers because of their ability to migrate and incorporate into inflammation areas including tumors. Here, this homing ability is exploited by carrying therapeutic nanoparticles (Hollow Gold Nanoparticles (HGNs)) following a “Trojan-horse” strategy. Amongst the different nanoparticles to be employed, HGNs have the capacity to resonate in the near infrared region when irradiated by an appropriated laser (808 nm). By transforming this absorbed energy into heat, they are capable to produce locally induced hyperthermia. At this wavelength healthy tissues have a minimal light absorption being the effect restricted to the tissues containing HGNs. By placing HGNs inside MSCs, the recognition, excretion and immune response are minimized. We demonstrate that MSCs internalize HGNs and reach the tumors still containing HGNs. After laser treatment this loaded cells are able to eradicate tumoral cells in vitro and in vivo without significant toxicity. Also Ki67 expression, which is usually correlated with proliferation, is reduced after treatment. This approach enhances the effectiveness of the treatment when compared to just the enhanced permeation and retention effect (EPR) of the HGNs by themselves.

Graphical abstract: Selective delivery of photothermal nanoparticles to tumors using mesenchymal stem cells as Trojan horses

Back to tab navigation

Supplementary files

Article information


Submitted
18 Apr 2016
Accepted
10 Jun 2016
First published
13 Jun 2016

RSC Adv., 2016,6, 58723-58732
Article type
Paper
Author version available

Selective delivery of photothermal nanoparticles to tumors using mesenchymal stem cells as Trojan horses

M. M. Encabo-Berzosa, M. Gimeno, L. Lujan, M. Sancho-Albero, L. Gomez, V. Sebastian, M. Quintanilla, M. Arruebo, J. Santamaria and P. Martin-Duque, RSC Adv., 2016, 6, 58723
DOI: 10.1039/C6RA10058A

Social activity

Search articles by author

Spotlight

Advertisements