Issue 112, 2016, Issue in Progress
From the journal:

RSC Advances

Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery†

PanKaj Garg,‡a   Shambhavi Pandey,‡a   Hong-Nam Kim,b   Hoon Seonwoo,a   Sunho Park,c   Kyoung Soon Choi,d   Kyoung-Je Jang,a   Hoon Hyun,e   Phil-Hoon Choung,*f   Jangho Kim*c  and  Jong Hoon Chung*a  

* Corresponding authors

a Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul, Republic of Korea
E-mail: jchung@snu.ac.kr

b Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea

c Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju, Republic of Korea
E-mail: rain2000@jnu.ac.kr

d Advanced Nano-Surface Research Group, Korea Basic Science Institute (KBSI), Daejeon 305-333, Republic of Korea

e Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 61469, Republic of Korea

f Department of Oral and Maxillofacial Surgery and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 110-774, Republic of Korea
E-mail: choungph@snu.ac.kr

Abstract

Here, we report the synergistic effects of hyperosmotic and nanotopographical cues designed using non-viral vectors and nanopatterned matrices for gene delivery. We show that efficiency of gene delivery can be further enhanced by two factors in combination, indicating the importance of synergistic cues in designing non-viral gene delivery platforms and strategies for gene therapy.

Graphical abstract: Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery

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Article information

DOI
https://doi.org/10.1039/C6RA09348E
Article type
Communication
Submitted
11 Apr 2016
Accepted
12 Nov 2016
First published
16 Nov 2016

RSC Adv., 2016,6, 111233-111238

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Synergistic effects of hyperosmotic polymannitol based non-viral vectors and nanotopographical cues for enhanced gene delivery

P. Garg, S. Pandey, H. Kim, H. Seonwoo, S. Park, K. S. Choi, K. Jang, H. Hyun, P. Choung, J. Kim and J. H. Chung, RSC Adv., 2016, 6, 111233 DOI: 10.1039/C6RA09348E

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