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Issue 68, 2016, Issue in Progress
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Metal-free C-3 alkylation of imidazopyridines with xanthates and convenient access to alpidem and zolpidem

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Abstract

A metal-free process for the C-3 alkylation of imidazopyridines has been developed. Various alkylation products including alkyl ester-, cyano-, ketone- and amide-substituted imidazopyridines were prepared in good yields. With this method, a highly efficient and concise formal synthesis of alpidem (A) and zolpidem (B) has been completed.

Graphical abstract: Metal-free C-3 alkylation of imidazopyridines with xanthates and convenient access to alpidem and zolpidem

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Article information


Submitted
08 Apr 2016
Accepted
24 Jun 2016
First published
28 Jun 2016

RSC Adv., 2016,6, 63532-63535
Article type
Communication

Metal-free C-3 alkylation of imidazopyridines with xanthates and convenient access to alpidem and zolpidem

S. Wang, X. Huang, Z. Ge, X. Wang and R. Li, RSC Adv., 2016, 6, 63532
DOI: 10.1039/C6RA09046J

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