Issue 57, 2016, Issue in Progress
From the journal:

RSC Advances

Iron-catalyzed addition/cyclization cascade of activated alkenes with alcohols: access to carbonyl substituted quinoline-2,4-diones†

Shi-Sheng Wang,a   Hong Fu,a   Guanlin Wang,a   Meng Sunb  and  Ya-Min Li*a  

* Corresponding authors

a Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P. R. China
E-mail: liym@kmust.edu.cn

b Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710127, P. R. China

Abstract

A convenient and efficient iron-catalyzed radical addition/cyclization cascade of o-cyanoarylacrylamides with alcohols is presented for the synthesis of carbonyl substituted quinoline-2,4(1H,3H)-diones in moderate to excellent yields. This transformation exhibits a wide substrate scope and significant functional group tolerance.

Graphical abstract: Iron-catalyzed addition/cyclization cascade of activated alkenes with alcohols: access to carbonyl substituted quinoline-2,4-diones

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Article information

DOI
https://doi.org/10.1039/C6RA08976C
Article type
Paper
Submitted
07 Apr 2016
Accepted
22 May 2016
First published
24 May 2016

RSC Adv., 2016,6, 52391-52394

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Iron-catalyzed addition/cyclization cascade of activated alkenes with alcohols: access to carbonyl substituted quinoline-2,4-diones

S. Wang, H. Fu, G. Wang, M. Sun and Y. Li, RSC Adv., 2016, 6, 52391 DOI: 10.1039/C6RA08976C

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