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Issue 63, 2016
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Novel rhodanines with anticancer activity: design, synthesis and CoMSIA study

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Abstract

Three different series of some novel N-substituted rhodanines were designed for anticancer activity and prepared from the corresponding dithiocarbamates. The synthesized compounds were analyzed by IR, NMR and MASS to confirm their structures. All the titled compounds were found to be of Z configuration based on NMR spectral analysis. All the synthesized rhodanines were screened for in vitro anticancer activity against MCF-7 breast cancer cells at the concentration of 10 μg. The compounds showed moderate to significant cytotoxicity. Amongst them, interestingly, compounds 10, 22 and 33 with cinnamoyl substitution at the 5th position of the thiazolidine ring system showed significant activity. Further, we subjected all these compounds to a CoMSIA study to study their 3D quantitative structure activity relationships (3D QSAR). The illustration about the design of novel rhodanines, synthesis, analysis, activity against MCF-7 cells and SAR via CoMSIA study are reported here.

Graphical abstract: Novel rhodanines with anticancer activity: design, synthesis and CoMSIA study

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Publication details

The article was received on 07 Apr 2016, accepted on 11 Jun 2016 and first published on 14 Jun 2016


Article type: Paper
DOI: 10.1039/C6RA08785J
RSC Adv., 2016,6, 58641-58653

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    Novel rhodanines with anticancer activity: design, synthesis and CoMSIA study

    S. P. Mandal, Mithuna, A. Garg, S. S. Sahetya, S. R. Nagendra, H. S. Sripad, M. M. Manjunath, Sitaram, M. Soni, R. N. Baig, S. V. Kumar and B. R. P. Kumar, RSC Adv., 2016, 6, 58641
    DOI: 10.1039/C6RA08785J

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