Issue 68, 2016, Issue in Progress

Total synthesis of (−)-(6R,11R,14S)-colletallol via proline catalyzed α-aminoxylation and Yamaguchi macrolactonization

Abstract

A simple and efficient synthesis of the 14-membered macrolide (−)-(6R,11R,14S)-colletallol was achieved in a highly diastereoselective manner with high overall yield. The stereogenic centre was generated using a proline catalyzed α-aminoxylation reaction and the ring was constructed using Yamaguchi protocol.

Graphical abstract: Total synthesis of (−)-(6R,11R,14S)-colletallol via proline catalyzed α-aminoxylation and Yamaguchi macrolactonization

Supplementary files

Article information

Article type
Paper
Submitted
02 Apr 2016
Accepted
21 Jun 2016
First published
23 Jun 2016

RSC Adv., 2016,6, 63607-63612

Total synthesis of (−)-(6R,11R,14S)-colletallol via proline catalyzed α-aminoxylation and Yamaguchi macrolactonization

S. V. Kauloorkar and P. Kumar, RSC Adv., 2016, 6, 63607 DOI: 10.1039/C6RA08484B

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