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Issue 60, 2016, Issue in Progress
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Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride) mixtures for wound care applications

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Abstract

Novel antimicrobial hydrogels with good mechanical and physical properties were synthesized by autoclaving aqueous mixtures of poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride). The structure of these materials was studied by infrared spectroscopy, scanning electron microscopy and solid state nuclear magnetic resonance. The swelling behavior, mechanical properties and adhesion of the hydrogels to porcine skin were evaluated. It was established that these hydrogels exhibited antimicrobial properties and inhibited bacteria growth against Staphylococcus aureus. The biocompatibility of the hydrogels was confirmed using an MTT assay (indirect cytotoxicity) and by monitoring cell proliferation in contact with the gels (direct cytotoxicity).

Graphical abstract: Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride) mixtures for wound care applications

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Publication details

The article was received on 30 Mar 2016, accepted on 28 May 2016 and first published on 01 Jun 2016


Article type: Paper
DOI: 10.1039/C6RA08234C
RSC Adv., 2016,6, 55211-55219
  • Open access: Creative Commons BY license
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    Antimicrobial hydrogels based on autoclaved poly(vinyl alcohol) and poly(methyl vinyl ether-alt-maleic anhydride) mixtures for wound care applications

    E. Caló, J. M. S. D. Barros, M. Fernández-Gutiérrez, J. San Román, L. Ballamy and V. V. Khutoryanskiy, RSC Adv., 2016, 6, 55211
    DOI: 10.1039/C6RA08234C

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