Jump to main content
Jump to site search

Issue 55, 2016, Issue in Progress
Previous Article Next Article

Characterization of a conglomerate-forming derivative of (±)-milnacipran and its enantiomeric resolution by preferential crystallization

Author affiliations

Abstract

Among some derivatives of milnacipran, a last-generation antidepressive drug with useful application in the treatment of fibromyalgia, N-isobutyramide (±)-4 was identified as a conglomerate-forming compound and characterized using a binary melting diagram and X-ray analysis. Exploiting the conglomerate nature of (±)-4, its enantiomeric resolution by preferential crystallization was shown to be feasible and allowed us to obtain both enantiomers in satisfactory yield and excellent optical purity over a few cycles of entrainment.

Graphical abstract: Characterization of a conglomerate-forming derivative of (±)-milnacipran and its enantiomeric resolution by preferential crystallization

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Mar 2016, accepted on 06 May 2016 and first published on 06 May 2016


Article type: Paper
DOI: 10.1039/C6RA07745E
RSC Adv., 2016,6, 49876-49882

  •   Request permissions

    Characterization of a conglomerate-forming derivative of (±)-milnacipran and its enantiomeric resolution by preferential crystallization

    C. Sanfilippo, A. Forni and A. Patti, RSC Adv., 2016, 6, 49876
    DOI: 10.1039/C6RA07745E

Search articles by author

Spotlight

Advertisements