Facile and eco-friendly synthesis of chromeno[4,3-b]pyrrol-4(1H)-one derivatives applying magnetically recoverable nano crystalline CuFe2O4 involving a domino three-component reaction in aqueous media

Abstract

Nanocrystalline CuFe₂O₄ catalyzed one pot three component synthesis of chromeno[4,3-b]pyrrol-4(1H)-one derivatives has been achieved in aqueous media. The reaction between the essential building blocks (amine, glyoxal monohydrate and 4-aminocoumarin) has been performed at low catalyst loading, leading to a high yield of the desired heterocyclic scaffold. CuFe₂O₄ magnetic nanoparticles were prepared by a simple and effective citric acid complex method and characterized by using XRD, FT-IR, EDX and TEM and HRTEM images. The easy recovery and reusability of the catalyst and operational simplicity of the process makes the protocol attractive, sustainable, and economic.