Issue 50, 2016, Issue in Progress
From the journal:

RSC Advances

Metal-free synthesis of quinazolinones without any additives in water†

Ben-Quan Hu,ab   Jie Cui,c   Li-Xia Wang,*b   Ya-Lin Tang*b  and  Luo Yang*a  

* Corresponding authors

a Key Laboratory for Environmental Friendly Chemistry and Application, Department of Chemistry, Xiangtan University, Hunan 411105, PR China
E-mail: yangluo@xtu.edu.cn

b Beijing National Laboratory for Molecular Sciences (BNLMS), Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China
E-mail: wlx8825@iccas.ac.cn, tangyl@iccas.ac.cn

c Center for Physicochemical Analysis and Measurement, Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing 100190, China

Abstract

Here we report that an excess amount of aldehyde, in particular, aliphatic aldehyde, without any additives, efficiently facilitates the oxidation of aminal intermediates to quinazolinones in pure water.

Graphical abstract: Metal-free synthesis of quinazolinones without any additives in water

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Article information

DOI
https://doi.org/10.1039/C6RA05777B
Article type
Communication
Submitted
04 Mar 2016
Accepted
19 Apr 2016
First published
20 Apr 2016

RSC Adv., 2016,6, 43950-43953

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Metal-free synthesis of quinazolinones without any additives in water

B. Hu, J. Cui, L. Wang, Y. Tang and L. Yang, RSC Adv., 2016, 6, 43950 DOI: 10.1039/C6RA05777B

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