Convenient synthesis of functionalized pyrrolo[3,4-b]pyridines and pyrrolo[3,4-b]quinolines via three-component reactions

Abstract

A simple protocol for convenient construction of pyrrolo[3,4-b]pyridine skeleton was successfully developed by base promoted three-component reaction of β-enamino imide, aromatic aldehydes and malononitrile as well as its ester and amide derivatives. The similar three-component reaction of β-enamino imide, aromatic aldehydes and cyclic diketones such as dimedone and cyclohexane-1,3-dione afforded functionalized pyrrolo[3,4-b]quinolines in good yields.