Zwitterionic cryogels for sustained release of proteins

Abstract

This work reports the preparation of zwitterionic cryogels for the sustained release of proteins for up to 4 months. In addition, high protein loading efficiency of up to 80% was achieved. Control studies with different hydrogels (such as non-ionic cryogels and non-ionic and zwitterionic gels prepared at room temperature) were performed to understand the mechanism behind the excellent protein loading and release properties of the zwitterionic cryogels.