Issue 29, 2016

One-pot synthesis of highly functionalized pyrimido[1,2-b]indazoles via 6-endo-dig cyclization

Abstract

An efficient synthesis of nitrogen ring junction pyrimido-indazoles has been developed. This is a metal catalyzed transformation that proceeds via A3 coupling reaction between 1H-indazol-3-amine, aromatic aldehydes and alkynes, which undergoes 6-endo-dig cyclization leading to the highly functionalized pyrimido[1,2-b]indazoles. Response surface methodology (RSM) was used to investigate the effect of catalyst (A1), reaction temperature (B1) and time (C1). The fluorescence quantum yields of the pyrimido[1,2-b]indazoles were calculated.

Graphical abstract: One-pot synthesis of highly functionalized pyrimido[1,2-b]indazoles via 6-endo-dig cyclization

Supplementary files

Article information

Article type
Paper
Submitted
28 Jan 2016
Accepted
26 Feb 2016
First published
29 Feb 2016

RSC Adv., 2016,6, 24610-24616

One-pot synthesis of highly functionalized pyrimido[1,2-b]indazoles via 6-endo-dig cyclization

J. Palaniraja, S. M. Roopan and G. M. Rayalu, RSC Adv., 2016, 6, 24610 DOI: 10.1039/C6RA02596J

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