Issue 59, 2016, Issue in Progress
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RSC Advances

A synthesized butyrolactone derivative in combination with chloroquine can inhibit cancer cell growth and lysosome vacuolation induced by chloroquine in A549 lung cancer cells†

Xin-Peng Chen,a   Chuan-Dong Fan,a   Le Su,a   Bao-Xiang Zhao*b  and  Jun-Ying Miao*a  

* Corresponding authors

a Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Science, Shandong University, Jinan 250100, China
E-mail: miaojy@sdu.edu.cn
Fax: +86 531 88565610
Tel: +86 531 88364929

b Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China
E-mail: bxzhao@sdu.edu.cn

Abstract

3BDO in combination with chloroquine could elevate the Na+,K+-ATPase activity and decrease the expression of long non-coding RNA TGFB2-OT1. Therefore, the combination inhibited the cell growth and lysosomal vacuolation.

Graphical abstract: A synthesized butyrolactone derivative in combination with chloroquine can inhibit cancer cell growth and lysosome vacuolation induced by chloroquine in A549 lung cancer cells

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Article information

DOI
https://doi.org/10.1039/C6RA02533A
Article type
Communication
Submitted
28 Jan 2016
Accepted
23 May 2016
First published
30 May 2016

RSC Adv., 2016,6, 54099-54101

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A synthesized butyrolactone derivative in combination with chloroquine can inhibit cancer cell growth and lysosome vacuolation induced by chloroquine in A549 lung cancer cells

X. Chen, C. Fan, L. Su, B. Zhao and J. Miao, RSC Adv., 2016, 6, 54099 DOI: 10.1039/C6RA02533A

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