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Issue 24, 2016
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Hollow silver alginate microspheres for drug delivery and surface enhanced Raman scattering detection

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Abstract

Multifunctional silver alginate hydrogel microspheres are assembled via a template assisted approach using calcium carbonate cores. Sodium alginate is immobilized into the highly porous structure of calcium carbonate microspheres followed by cross-linking in the presence of silver ions. The simultaneous processes of the growth of silver nanoparticles in the alginate matrix and the removal of the calcium carbonate template are triggered by ascorbic acid. The abundance of silver nanoparticles and their interparticular junctions in the alginate network allow for the detection of solutes using Raman spectroscopy using the surface of the plasmonic microspheres. Rhodamine B was used to illustrate the potential applications of such multifunctional plasmonic alginate hydrogel microspheres for sensing at low concentrations. A proof of principle for using such particles for the quick identification of microorganisms is then demonstrated using the Escherichia coli bacterium.

Graphical abstract: Hollow silver alginate microspheres for drug delivery and surface enhanced Raman scattering detection

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Publication details

The article was received on 22 Jan 2016, accepted on 04 Feb 2016 and first published on 05 Feb 2016


Article type: Communication
DOI: 10.1039/C6RA02019D
Citation: RSC Adv., 2016,6, 20447-20452
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    Hollow silver alginate microspheres for drug delivery and surface enhanced Raman scattering detection

    E. Lengert, A. M. Yashchenok, V. Atkin, A. Lapanje, D. A. Gorin, G. B. Sukhorukov and B. V. Parakhonskiy, RSC Adv., 2016, 6, 20447
    DOI: 10.1039/C6RA02019D

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