Magnetic nanoporous hybrid carbon from core–shell metal–organic frameworks for glycan extraction

Abstract

Magnetic nanoporous carbon (NPC) materials, which can be thoroughly separated from an aqueous solution easily, are very promising adsorbents. In this study, magnetic nanoporous hybrid carbon materials were synthesized as a novel enrichment platform for glycan analysis using core–shell metal–organic frameworks (MOFs) as a sacrificial template and carbon precursor. The designed and synthesized magnetic nanoporous hybrid carbon materials possessed hybrid merits, including high surface area, cut-off effect of uniform pore size, high graphitic carbon content and strong magnetic response. Considering the specific interaction between graphitized carbons and glycan, the magnetic nanoporous hybrid carbon materials with good repeatability were successfully used to enrich N-glycans from both standard protein digests and human serum.