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Issue 19, 2016
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Peganumine B-I and two enantiomers: new alkaloids from the seeds of Peganum harmala Linn. and their potential cytotoxicity and cholinesterase inhibitory activities

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Abstract

Ten new alkaloids (peganumine B-I and two enantiomers), containing five β-carbolines, three quinazolones, two compounds with both of the above skeletons, and one amphoteric alkaloid with a four-membered ring, were isolated from the ethanol extract of Peganum harmala. Their structures were elucidated on the basis of spectral data using 1D and 2D NMR, X-ray crystallographic analysis, CD, and ECD. Peganumine B showed potential inhibitory activity against both AChE and BChE with IC50 values of 0.25 ± 0.04, and 1.45 ± 0.34 μM, respectively. Peganumine C, peganumine D, and peganumine I were found to have selective inhibitory activity against AChE with IC50 values of 14.38 ± 2.49, 5.71 ± 1.22, and 7.17 ± 1.45 μM, respectively. Peganumine G and peganumine H showed significant cytotoxicity against a ZR-75-1 cell line with IC50 values of 6.20 ± 2.71, and 2.43 ± 0.79 μM, respectively.

Graphical abstract: Peganumine B-I and two enantiomers: new alkaloids from the seeds of Peganum harmala Linn. and their potential cytotoxicity and cholinesterase inhibitory activities

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Publication details

The article was received on 03 Jan 2016, accepted on 22 Jan 2016 and first published on 26 Jan 2016


Article type: Paper
DOI: 10.1039/C6RA00086J
Citation: RSC Adv., 2016,6, 15976-15987
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    Peganumine B-I and two enantiomers: new alkaloids from the seeds of Peganum harmala Linn. and their potential cytotoxicity and cholinesterase inhibitory activities

    Y. Yang, X. Cheng, W. Liu, Z. Han, G. Chou, Y. Wang, D. Sun, Z. Wang and C. Wang, RSC Adv., 2016, 6, 15976
    DOI: 10.1039/C6RA00086J

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