Issue 30, 2016

A two-step continuous synthesis of α-ketoamides and α-amino ketones from 2° benzylic alcohols using hydrogen peroxide as an economic and benign oxidant

Abstract

A practical two-step synthesis of α-ketoamides and α-amino ketones via direct oxidative coupling between 2° benzylic alcohols and amines was developed. Hydrogen peroxide, an economic and environmentally friendly oxidant, was used, and a metal catalyst was unnecessary. Moreover, the continuous-flow technique was employed to increase the functional group tolerance, efficiency and safety.

Graphical abstract: A two-step continuous synthesis of α-ketoamides and α-amino ketones from 2° benzylic alcohols using hydrogen peroxide as an economic and benign oxidant

Supplementary files

Article information

Article type
Paper
Submitted
24 Dec 2015
Accepted
29 Feb 2016
First published
01 Mar 2016

RSC Adv., 2016,6, 25167-25172

A two-step continuous synthesis of α-ketoamides and α-amino ketones from 2° benzylic alcohols using hydrogen peroxide as an economic and benign oxidant

C. Liu, Z. Fang, Z. Yang, Q. Li, S. Guo and K. Guo, RSC Adv., 2016, 6, 25167 DOI: 10.1039/C5RA27653E

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