Nano-FGT: a green and sustainable catalyst for the synthesis of spirooxindoles in aqueous medium

Abstract

A glutathione grafted nano-organocatalyst (nano-FGT) was used as an efficient catalyst for the synthesis of spirooxindole derivatives. An aqueous medium, easy separation by an external magnet, efficient catalyst reusability, low catalyst loading, and column chromatography free separation of the product makes the present procedure green, sustainable and economically viable. The TON and TOF of the nanocatalyst reached 850 000 and 56 667 min⁻¹ respectively.