Issue 26, 2016
From the journal:

RSC Advances

Acid-promoted rapid solvent-free access to substituted 1,4-dihydropyridines from β-ketothioamides†

Ming Li,*a   Ke-Na Suna  and  Li-Rong Wen*a  

* Corresponding authors

a State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China
E-mail: wenlirong@qust.edu.cn, liming928@qust.edu.cn

Abstract

β-Ketothioamides (KTAs) have been used as building blocks with aldehydes and β-enaminonitriles for synthesis of 1,4-dihydropyridines in the presence of AcOH under solvent-free conditions within 5 min. This new strategy exhibits remarkable features such as high chemoselectivity, mild reaction conditions, easily available substrates, and good yields.

Graphical abstract: Acid-promoted rapid solvent-free access to substituted 1,4-dihydropyridines from β-ketothioamides

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5RA26931H
Article type
Paper
Submitted
16 Dec 2015
Accepted
15 Feb 2016
First published
16 Feb 2016

RSC Adv., 2016,6, 21535-21539

Permissions

Request permissions

Acid-promoted rapid solvent-free access to substituted 1,4-dihydropyridines from β-ketothioamides

M. Li, K. Sun and L. Wen, RSC Adv., 2016, 6, 21535 DOI: 10.1039/C5RA26931H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements