Nano-NiFe2O4 catalyzed microwave assisted one-pot regioselective synthesis of novel 2-alkoxyimidazo[1,2-a]pyridines under aerobic conditions

Abstract

Here, we have demonstrated an efficient and regioselective protocol for the synthesis of novel 2-alkoxy-3-arylimidazo[1,2-a]pyridines via microwave (MW) assisted one-pot reactions of 2-aminopyridine, β-nitrostyrenes and alcohols using nano-NiFe₂O₄ as a reusable catalyst under aerobic conditions. This is the first method to produce alkoxy functionalized imidazopyridine moieties furnished via sequential one-pot three component reactions. The MW irradiation expedited the reaction rate and increased the yield of products.