Issue 12, 2016

Schoberine B, an alkaloid with an unprecedented straight C5 side chain, and myriberine B from Myrioneuron faberi

Abstract

Two novel Myrioneuron alkaloids, schoberine B (1) and myriberine B (2), were isolated from the aerial part of Myrioneuron faberi. Schoberine B is the first example among lysine-originating alkaloids to possess a ring-free C5 fragment as a side chain. The structures of 1 and 2 were elucidated using analyses of extensive NMR and MS spectra. 1 and 2 were evaluated in vitro against hepatitis C virus (HCV), showing a therapeutic index (CC50/EC50) of higher than 36.2 and 15.2, respectively.

Graphical abstract: Schoberine B, an alkaloid with an unprecedented straight C5 side chain, and myriberine B from Myrioneuron faberi

Supplementary files

Article information

Article type
Communication
Submitted
27 Nov 2015
Accepted
14 Jan 2016
First published
18 Jan 2016

RSC Adv., 2016,6, 10180-10184

Schoberine B, an alkaloid with an unprecedented straight C5 side chain, and myriberine B from Myrioneuron faberi

M. Cao, Y. Zhang, Z. Peng, J. Jiang, Y. Gao and X. Hao, RSC Adv., 2016, 6, 10180 DOI: 10.1039/C5RA25218K

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