Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 22, 2016
Previous Article Next Article

Substrate induced diastereoselective hydrogenation/reduction of arenes and heteroarenes

Author affiliations

Abstract

Chiral, either racemic or optically pure, substituted cyclohexanes, piperidines, tetrahydrofurans and pyrrolidines can be prepared by the diastereoselective hydrogenation/reduction of the corresponding aromatic and heteroaromatic precursors, exploiting the presence of one or more stereocenters present in the ring substituent(s), where the sense and level of asymmetric induction can be the result of different factors: the rigidity or flexibility of the substrate, the presence of an appropriate functionality in the lateral substituent which can stabilize a particular conformation of the molecule, especially in pyridine and furan derivatives, the nature of the catalyst or the reducing system, and the experimental conditions.

Graphical abstract: Substrate induced diastereoselective hydrogenation/reduction of arenes and heteroarenes

Back to tab navigation

Article information


Submitted
12 Nov 2015
Accepted
21 Jan 2016
First published
26 Jan 2016

RSC Adv., 2016,6, 18419-18451
Article type
Review Article
Author version available

Substrate induced diastereoselective hydrogenation/reduction of arenes and heteroarenes

A. Gualandi and D. Savoia, RSC Adv., 2016, 6, 18419
DOI: 10.1039/C5RA23908G

Social activity

Search articles by author

Spotlight

Advertisements