Issue 13, 2016

Combinatorial synthesis of spiro[indoline-3,2′-pyrrole] derivatives via a three-component reaction under catalyst-free conditions

Abstract

Reported here is a convenient catalyst-free method for preparing a series of spiro[indoline-3,2′-pyrroles] from a three-component reaction of isatins, α-amino acid and phenylpropiolic acid esters in refluxing isopropanol with high regioselectivity and yields. A plausible mechanism for this process was proposed. In addition, this protocol permitted the facile construction of spiro[indoline-3,2′-pyrroles] through an expanded scope of substrates.

Graphical abstract: Combinatorial synthesis of spiro[indoline-3,2′-pyrrole] derivatives via a three-component reaction under catalyst-free conditions

Supplementary files

Article information

Article type
Paper
Submitted
12 Nov 2015
Accepted
19 Jan 2016
First published
19 Jan 2016

RSC Adv., 2016,6, 10412-10418

Combinatorial synthesis of spiro[indoline-3,2′-pyrrole] derivatives via a three-component reaction under catalyst-free conditions

G. Shi, X. He, Y. Shang and M. Xie, RSC Adv., 2016, 6, 10412 DOI: 10.1039/C5RA23860A

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