Jump to main content
Jump to site search

Issue 15, 2016
Previous Article Next Article

Synergistic effect of quercetin and 6-gingerol treatment in streptozotocin induced type 2 diabetic rats and poloxamer P-407 induced hyperlipidemia

Author affiliations

Abstract

Ginger and quercetin have been reported to have significant antidiabetic effects. It has been proposed that 6-gingerol and quercetin are responsible for the antidiabetic activity and that a combination of the two produces a synergistic effect. However, the per se effect of 6-gingerol has not been reported. The objective of this study was to investigate the effects of 6-gingerol and quercetin per se, on streptozotocin induced non-insulin dependent diabetes mellitus (NIDDM) and hyperlipidemia. 6-Gingerol and quercetin reduced fasting glucose significantly with producing significant changes in the insulin levels of diabetic rats. The amelioration was significantly more with the combination, compared with either compound alone. The results of the oral glucose tolerance test (OGTT) indicated that 6-gingerol and quercetin reduced streptozotocin (STZ) induced increases in both area under curve glucose (AUCglucose) and area under curve insulin (AUCinsulin) in high fat feed type 2 diabetic rats. Treatment with 6-gingerol and quercetin reduced the levels of lipids in rats with NIDDM significantly. 6-Gingerol and quercetin had antihyperlipidemic effects in polaxamer P-407-induced hyperlipidemia. Quercetin and 6-gingerol show reduced serotonin induced hyperglycemia. This is the first study to demonstrate synergism of 6-gingerol and quercetin that has significant antidiabetic and beneficial cardiac effects in type 2 diabetic rats and polaxamer-induced hyperlipidemic rats. The synergistic action is probably through modulation of the serotonergic system.

Graphical abstract: Synergistic effect of quercetin and 6-gingerol treatment in streptozotocin induced type 2 diabetic rats and poloxamer P-407 induced hyperlipidemia

Back to tab navigation

Article information


Submitted
16 Aug 2015
Accepted
18 Jan 2016
First published
01 Feb 2016

RSC Adv., 2016,6, 12235-12242
Article type
Paper
Author version available

Synergistic effect of quercetin and 6-gingerol treatment in streptozotocin induced type 2 diabetic rats and poloxamer P-407 induced hyperlipidemia

Y. Shao, Y. Yu, C. Li, J. Yu, R. Zong and C. Pei, RSC Adv., 2016, 6, 12235
DOI: 10.1039/C5RA16493A

Social activity

Search articles by author

Spotlight

Advertisements