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Issue 4, 2016
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Glutathione modified carbon-dots: from aggregation-induced emission enhancement properties to a “turn-on” sensing of temperature/Fe3+ ions in cells

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Abstract

In this paper, a novel “turn-on” chemosensor for detecting temperature and Fe3+ has been designed. This nanosensor is based on the aggregation-induced emission enhancement (AIEE) properties of fluorescent carbon dots (CDs). The CDs prepared by a facile hydrothermal route show blue emission (λem = 505 nm) with a quantum yield of 4.7%. The resultant CDs are modified by glutathione (GSH) on the surface through the carbodiimide-activated coupling reaction. The as-prepared GSH-CDs show good dispersion, high fluorescence and AIEE phenomenon. Resultant GSH-CDs would be aggregated by Fe3+ ions in aqueous solution which results in enhanced fluorescence. Therefore, such GSH-CDs would be excellent candidates as fluorescent probes for the label-free detection of Fe3+ ions with a limit of detection of 0.1 μM. Moreover, the PL intensity of GSH-CDs increases progressively with increasing temperature and they could be used in optical thermometry over a wide temperature range (25–80 °C) with small temperature resolution (∼0.5 °C). Using MC3T3-E1 cells as the model, the resultant nanosensor is demonstrated to monitor temperature and Fe3+ ions in cells. Thus, resultant GSH-CDs could be used as a “turn-on” sensor for highly sensitive and selective detection of temperature and Fe3+ ions in aqueous solution and biosystems.

Graphical abstract: Glutathione modified carbon-dots: from aggregation-induced emission enhancement properties to a “turn-on” sensing of temperature/Fe3+ ions in cells

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Publication details

The article was received on 03 Dec 2015, accepted on 11 Jan 2016 and first published on 13 Jan 2016


Article type: Research Article
DOI: 10.1039/C5QI00273G
Citation: Inorg. Chem. Front., 2016,3, 514-522
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    Glutathione modified carbon-dots: from aggregation-induced emission enhancement properties to a “turn-on” sensing of temperature/Fe3+ ions in cells

    C. Wang, K. Jiang, Z. Xu, H. Lin and C. Zhang, Inorg. Chem. Front., 2016, 3, 514
    DOI: 10.1039/C5QI00273G

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