Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding

Bo Wang; Thomas Blin; Aleksandr Käkinen; Xinwei Ge; Emily H. Pilkington; John F. Quinn; Michael R. Whittaker; Thomas P. Davis; Pu Chun Ke; Feng Ding

doi:10.1039/C6PY01480A

Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding†

Bo Wang,^a Thomas Blin,^b Aleksandr Käkinen,^b Xinwei Ge,^a Emily H. Pilkington,^b John F. Quinn,^b Michael R. Whittaker,^b Thomas P. Davis,*^bc Pu Chun Ke*^b and Feng Ding*^a

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* Corresponding authors

^a Department of Physics and Astronomy, Clemson University, Clemson, SC, USA
E-mail: fding@clemson.edu

^b ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia
E-mail: thomas.p.davis@monash.edu, pu-chun.ke@monash.edu

^c Department of Chemistry, University of Warwick, Gibbet Hill, Coventry, CV4 7AL, UK

Abstract

To provide a molecular insight for guiding polymer coating in surface science and nanotechnology, here we examined the structures of brushed polyethylene glycol(bPEG)- and phosphorylcholine(bPC)-grafted iron oxide nanoparticles and analyzed their protein avoiding properties. We show bPC as an advantageous biomimetic alternative to PEG in rendering stealth nanostructures.

Polymer Chemistry

Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding†

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Brushed polyethylene glycol and phosphorylcholine for grafting nanoparticles against protein binding

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