Jump to main content
Jump to site search

Issue 38, 2016
Previous Article Next Article

Non-covalent interactions in controlling pH-responsive behaviors of self-assembled nanosystems

Author affiliations

Abstract

Self-assembly and associated dynamic and reversible non-covalent interactions are the basis of protein biochemistry (e.g., protein folding) and the development of sophisticated nanomaterial systems that can respond to and amplify biological signals. In this study, we report a systematic investigation on non-covalent interactions that affect the pH responsive behaviors and the resulting supramolecular self-assembly of a series of ultra-pH sensitive (UPS) block copolymers. An increase of hydrophobic and π–π stacking interactions led to a decrease of pKa values. In contrast, enhancement of direct ionic binding between cationic ammonium groups and anionic counter ions gave rise to increased pKa. Moreover, hydration of hydrophobic surfaces and hydrogen bonding interactions may also play a role in the self-assembly process. The key parameters capable of controlling the subtle interplay of different non-covalent bonds in the pH-triggered self-assembly of UPS copolymers are likely to offer molecular insights to understand other stimuli-responsive nanosystems. Selective and precise implementation of non-covalent interactions in stimuli-responsive self-assembly processes will provide powerful and versatile tools for the development of dynamic, complex nanostructures with predictable and tunable transitions.

Graphical abstract: Non-covalent interactions in controlling pH-responsive behaviors of self-assembled nanosystems

Back to tab navigation

Supplementary files

Article information


Submitted
24 Jun 2016
Accepted
30 Aug 2016
First published
30 Aug 2016

Polym. Chem., 2016,7, 5949-5956
Article type
Paper

Non-covalent interactions in controlling pH-responsive behaviors of self-assembled nanosystems

Y. Li, Z. Wang, Q. Wei, M. Luo, G. Huang, B. D. Sumer and J. Gao, Polym. Chem., 2016, 7, 5949
DOI: 10.1039/C6PY01104G

Social activity

Search articles by author

Spotlight

Advertisements